Bone mineralization problems and nutritional D deficit: histomorphometric studies away from iliac crest bone biopsies and you will releasing twenty-five-hydroxyvitamin D for the 675 people. J Bones Miner Res 2010; 25: 305–312.
Zhou Y, Zhao LJ, Xu X ainsi que al. DNA methylation quantities of CYP2R1 and you will CYP24A1 expect supplement D impulse version. J Steroid Biochem Mol Biol 2014; 144: 207–214.
Ralston SH, Binkley N, Boonen S et al. Randomized demonstration regarding alendronate also supplement D3 versus fundamental care inside the osteoporotic postmenopausal people which have supplement D insufficiency. Calcif Muscle Int 2011; 88: 485–494.
Weber K, Kaschig C, Erben RG . step one Alpha-hydroxyvitamin D2 and you will 1 leader-hydroxyvitamin D3 have anabolic effects on cortical limbs, however, trigger intracortical renovations in the harmful doses inside the ovariectomized mice. Bone 2004; 35: 704–710.
Li Meters, Healy DR, Simmons HA mais aussi al. Alfacalcidol restores cancellous bones when you look at the ovariectomized rats. J Musculoskelet Neuronal Work together 2003; 3: 39–46.
Procedures which have elage, and you will collagen crosslinks inside the primate limbs
Orimo H, Shiraki Meters, Hayashi mormon dating sites Y ainsi que al. Negative effects of step one alpha-hydroxyvitamin D3 to the lumbar bones nutrient occurrence and you may vertebral splits for the clients which have postmenopausal osteoporosis. Calcif Muscle Int 1994; 54: 370–376.
Shikari Kushida Meters, Yamazaki K, Nagai K ainsi que al. H. Aftereffects of dos years’ therapy of osteoporosis which have step 1 alpha-hydroxy vitamin D3 into the bone mineral density and chance from crack: a beneficial placebo-managed, double-blind prospective analysis. Endocr J 1996; 43: 211–220.
Nuti Roentgen, Bianchi G, Brandi ML ainsi que al. Superiority of alfacalcidol versus nutritional D and additionally calcium during the lumbar limbs mineral density during the postmenopausal osteoporosis. Rheumatol Int 2006; 26: 445–453.
Kubodera N, Tsuji N, Uchiyama Y et al. A new active vitamin D analogue, ED-71, causes increase in bone size having preferential outcomes into the bone for the osteoporotic clients. J Cell Biochem 2003; 88: 286–289.
Abe Yards, Tsuji N, Takahashi F mais aussi al. Breakdown of brand new scientific pharmacokinetics off elin D3 by-product. Jpn Pharmacol Ther 2011; 39: 261–274.
Ritter CS, Brownish AJ . Inhibition out-of PTH by vitamin D analogue eldecalcitol try modulated because of the the large attraction into the serum vitamin D-binding necessary protein and you may resistance to k-calorie burning. J Mobile Biochem 2011; 112: 1348–1352.
Kondo S, Takano T, Ono Y et al. Eldecalcitol decreases osteoporotic fractures of the novel systems. J Steroid Biochem Mol Biol 2015; 148: 232–238.
Harada S, Mizoguchi T, Kobayashi Y mais aussi al. Each day government off elin D analog, grows bone nutrient occurrence of the suppressing RANKL expression inside the mouse trabecular limbs. J Bone Miner Res 2012; 27: 461–473.
Hayashi Y, Fujita T, Inoue T
Matsumoto T, Ito M, Hayashi Y mais aussi al. A separate effective vitamin D3 analog, eldecalcitol, suppress the possibility of osteoporotic fractures–a beneficial randomized, productive comparator, double-blind investigation. Limbs 2011; 49: 605–612.
Matsumoto T, Takano T, Saito H mais aussi al. Nutritional D analogs and you can bones: preclinical and you will scientific studies which have el; 3: 513.
Sakai Good, Ito Meters, Tomomitsu T et al. Efficacy out-of joint medication which have alendronate (ALN) and you can elin D analog, to that out-of concomitant ALN, vitamin D plus calcium supplements treatment in the Japanese patients that have pri; 26: 1193–1202.
Plum Los angeles, Fitzpatrick Los angeles, Ma X ainsi que al. 2MD, a separate anabolic broker getting weakening of bones treatment. Osteoporos Int 2006; 17: 704–715.
Ke HZ, Qi H, Crawford DT ainsi que al. An alternate supplement D analog, 2MD, restores trabecular and you will cortical bone size and you may electricity during the ovariectomized mice that have based osteopenia. J Bone Miner Res 2005; 20: 1742–1755.
DeLuca HF, Bedale W, Binkley Letter mais aussi al. The latest vitamin D analogue 2MD expands bones return but not BMD inside the postmenopausal female which have osteopenia: consequence of a-1-12 months stage dos twice-blind, placebo-regulated, randomized clinical test. J Bone Miner Res 2011; 26: 538–545.